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HRID505408

反应详情

EQUATION

反应方程式

HRID 505408 的结构方程式

REACTANTS

反应物

2
结构：OB(O)c1cccc(OCc2ccccc2)c1
HCID2734313

3-Benzyloxybenzeneboronic Acid

C13H13BO3

结构：Cc1cc(N)nc(CCc2nc3cc(Br)cnc3[nH]2)c1
HCID178428704

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(N)nc(CCc2nc3cc(-c4cccc(OCc5ccccc5)c4)cnc3[nH]2)c1
HCID178428710

未命名化合物

收率 61%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O=C([O-])[O-].[Na+].[Na+]
溶剂HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

The title compound is synthesized according to General Procedure A. 150 mg of 2-[2-(2-amino4-methylpyridin-6-yl)ethyl]-6-bromo-3H-imidazo[4,5-b]pyridine in 7.5 ml dioxane, 1.36 ml Na2CO3 solution, 116 mg of 3-benzyloxyphenylboronic acid, 20 mg of PdCl2(PCy3)2, 120° C. for 48 h, 20 ml of CH2Cl2/H2O, 220 mg of crude title compound is purified by re-crystallization from 6.0 ml isopropyl alcohol to yield 120 mg of the title compound. M.p. 181° C. ESI-MS: 436.3 (MH+). TLC: Rf=0.30 (dichloromethane/methanol 10:1).

WORKUP

后处理

  1. customThe title compound is synthesized
  2. custom20 ml of CH2Cl2/H2O, 220 mg of crude title compound is purified by re-crystallization from 6.0 ml isopropyl alcohol