Methacrylonitrile → HCID 15984010, compound

Participants

Reaction Steps

To a mixture of compound obtained from step b above (50 mg, 0.218 mmol) and methylacrylonitrile (29.3 mg, 0.436 mmol) was added tetrahydrofuran (5 ml) and stirred the reaction mixture for 10 minutes at room temperature. To the resulting reaction mixture was added sodium hypochlorite (3 ml) with vigorous stirring, which was continued for 15 hours. The solvent was evaporated under reduced pressure and extracted the compound with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulphate and concentrated under reduced pressure to furnish the title compound. The residue thus obtained was purified by column chromatography using ethylacetate in hexane solvent mixture as eluent to furnish the title compound. Yield: 65 mg.

Provenance & Evidence