4-Ethynyl-N,N-dimethylaniline → HCID 15603447, compound

HRID 505458Notes

Reaction equation

HRID 505458 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH3:11])[CH3:10])=[CH:5][CH:4]=1)#[CH:2].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([N:24]=[N+:25]=[N-:26])[CH:17]=[C:18]([O:22][CH3:23])[C:19]=1[O:20][CH3:21]>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([N:24]2[C:1]([C:3]3[CH:8]=[CH:7][C:6]([N:9]([CH3:11])[CH3:10])=[CH:5][CH:4]=3)=[CH:2][N:26]=[N:25]2)[CH:17]=[C:18]([O:22][CH3:23])[C:19]=1[O:20][CH3:21]

Participants

3

Reactant 2

HCID 51918844-Ethynyl-N,N-dimethylanilineHCID 59430102HCID 59430102, compound

Product 1

HCID 15603447HCID 15603447, compound

Conditions

Temperature
80 °C

Procedure

To a scintillation vial was added (4-ethynyl phenyl)-dimethyl amine (660 5 mmol) and 3,4,5-trimethoxyphenyl azide (1.05 g.; 5 mmol) and the mixture was heated at 80° C. for 24 hours. The crude mixture was purified by column chromatography to give 1-(3,4,5-trimethoxy-phenyl)-5-[4-(N,N-dimethylamino)-phenyl]-1H-[1,2,3]triazole.

Workup

  1. customThe crude mixture was purified by column chromatography

Sources & evidence

ORD record
ord-d6342041c0d84c67adf62e84ad22a8f5
Source dataset
uspto-grants-2010_08
Patent number
US07781462B2

Reaction notes

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