HRID505490

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15835

4-Methylcinnamic acid

C10H10O2

结构：COC(=O)[C@@H](N)Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c(Br)c1

HCID68445645

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(C=CC(=O)N[C@@H](Cc2ccc(OCCc3nc(-c4ccccc4)oc3C)c(Br)c2)C(=O)O)cc1

HCID68445072

未命名化合物

收率 24%

PROCEDURE

实验过程

Following the procedures described in Example 1, Intermediate 3B was used in place of Intermediate 3A, and 4-methylcinnamic acid was used in place of cinnamic acid to give (2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-phenyl}-2-(3-p-tolylacryloylamino)-propanoic acid as a white solid with the yield of 24% and mp of 243˜245° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a06641ca0bd2486eb8ce7461f79195e1
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07781468B2
来源说明: uspto-grants-2010_08

反应 SMILES

C[O:2][C:3](=[O:29])[C@@H:4]([NH2:28])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:18][C:19]=2[CH3:20])=[C:8]([Br:27])[CH:7]=1.[CH3:30][C:31]1[CH:41]=[CH:40][C:34]([CH:35]=[CH:36][C:37](O)=[O:38])=[CH:33][CH:32]=1>>[Br:27][C:8]1[CH:7]=[C:6]([CH2:5][C@H:4]([NH:28][C:37](=[O:38])[CH:36]=[CH:35][C:34]2[CH:40]=[CH:41][C:31]([CH3:30])=[CH:32][CH:33]=2)[C:3]([OH:2])=[O:29])[CH:11]=[CH:10][C:9]=1[O:12][CH2:13][CH2:14][C:15]1[N:16]=[C:17]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[O:18][C:19]=1[CH3:20]