HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fluorocinnamic acid → HCID 68443237, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fluorocinnamic acid | HCID 98321 | — |
| Reactant | (2S)-2-Amino-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid methyl ester | HCID 68445645 | — |
| Product | HCID 68443237 | HCID 68443237 | 25% |
Reaction Steps
Following the procedures described in Example 1, Intermediate 3B was used in place of Intermediate 3A, and 2-fluoro-3-phenyl-acrylic acid was used in place of cinnamic acid to give (2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-ethoxy]-phenyl}-2-(2-fluoro-3-phenyl-acryloylamino)-propanoic acid as a white solid with the yield of 25% and mp of 243˜245° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781468B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-fd99cb701e914fb1a1263246ae18f465 |
| Source note | uspto-grants-2010_08 |