Potassium Carbonate → tert-Butyl 5-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate

Participants

Reaction Steps

To a solution of t-butyl 5-(acetyloxy)-3,4-dihydroquinoline-1(2H)-carboxylate (770 mg, 2.64 mmol) in 10 mL of MeOH was added potassium carbonate (365 mg, 2.64 mmol), and the resulting mixture was stirred for 2 hours at room temperature and then filtered and concentrated in vacuo. The crude material was purified on a silica gel column (5% to 35% EtOAc/hexanes) to afford the desired product.

Provenance & Evidence