反应详情

20.0 g (0.13 mol) of 5-fluoro-2-methoxybenzaldehyde are dissolved in 205 ml of methanol. Under argon, 2.45 g (54.9 mol) of sodium borohydride are added in small portions. The solution is stirred at RT for 4 hours. The solution is concentrated and the residue is taken up in water and stirred for 30 min. The aqueous phase is extracted with ethyl acetate and the organic phase is dried over magnesium sulphate, filtered and evaporated under reduced pressure.

1. concentrationThe solution is concentrated
2. stirringstirred for 30 min
3. extractionThe aqueous phase is extracted with ethyl acetate
4. dry with materialthe organic phase is dried over magnesium sulphate
5. filtrationfiltered
6. customevaporated under reduced pressure