HCID 10411996, compound → HCID 11744377, compound

Participants

Reaction Steps

(1-(2-Bromobenzenesulfonyl)-1H-indol-3-yl)-(4-methylpiperazin-1-yl)methanone (0.93 g, 0.002 moles) in THF (10 mL) was treated with cooled and stirred suspension of LAH (0.04 g, 0.001 moles) in THF (10 mL) slowly over the period of 2 to 5 hours, the reaction mixture was heated to reflux for 2-4 hours. After the completion of reaction, the reaction mixture was poured on to the ice and the compound was extracted with ethyl acetate. The residue obtained was purified by flash chromatography (silica gel, EtOAc/Hexanes, 2/8) to afford the compound, which was identified by IR, NMR and mass spectral analyses as the title compound.

Provenance & Evidence