Hydrochloric Acid → HCID 23147512, compound

Participants

Reaction Conditions

Reaction Steps

The above-obtained 3-ethyl-2-(methoxycarbonylmethyl)-4,6-bis(methoxymethoxy)benzoic acid methyl ester (1.1 g, 3.0 mmol) was dissolved in methanol (3 mL) and the obtained solution was added with 4.0 mol/L aqueous lithium hydroxide solution (15 mL, 60 mmol) followed by stirring at 60° C. for 30 hours. The reaction mixture was added with water and 6.0 mol/L hydrochloric acid and the pH value was adjusted to 3. Then, the mixture was extracted with ethyl acetate 3 times. The organic layers were combined and dried over anhydrous sodium sulfate. Then, the solvent was evaporated under reduced pressure to obtain 2-(carboxymethyl)-3-ethyl-4,6-bis(methoxymethoxy)benzoic acid (0.91 g, 94%).

Provenance & Evidence