Sodium Sulfate → HCID 86616384, compound

Participants

Reaction Conditions

Reaction Steps

The above-obtained [2-(N-benzylcarbamoyl)-6-ethyl-3,5-bis(methoxymethoxy)phenyl]acetic acid methyl ester (46 mg, 0.11 mmol) was dissolved in tetrahydrofuran (5 mL) and cooled to 0° C. The obtained solution was added with 1.0 mol/L lithium aluminum hydride-tetrahydrofuran solution (0.20 mL, 0.20 mmol) followed by stirring at 0° C. for 0.5 hour. The reaction mixture was added with saturated aqueous sodium sulfate solution, and was extracted with ethyl acetate 3 times. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and then the solvent was evaporated under reduced pressure. The residue was purified by preparative thin-layer chromatography (hexane/ethyl acetate=1/1) to obtain N-benzyl-3-ethyl-2-(2-hydroxyethyl)-4,6-bis(methoxymethoxy)benzamide (30 mg, 74%).

Provenance & Evidence