Hydrochloric Acid → 2-(Benzyloxymethyl)-4,6-dihydroxybenzoic acid methyl ester

Participants

Reaction Conditions

Reaction Steps

The above-obtained 2-(benzyloxymethyl)-4,6-bis(methoxymethoxy)benzoic acid methyl ester (10 mg, 0.027 mmol) was dissolved in ethanol (4 mL) and the obtained solution was added with concentrated hydrochloric acid (0.10 mL) and stirred at 60° C. for 1 hour. The reaction mixture was concentrated under reduced pressure, and the residue was purified by preparative thin-layer chromatography (chloroform/methanol=20/1) to obtain Compound 22 (12 mg, 100%).

Provenance & Evidence