反应详情

To a solution of 2-bromo-5-trifluoromethylaniline (3.18 g, 13.25 mmol) in pyridine (18 ml) was added methanesulfonyl chloride (1.03 ml, 13.25 mmol) and the mixture was stirred for 6 hours at room temperature. The solvent was removed in vacuo and the residue was diluted with chloroform. The organic layer was washed with water, 1N hydrochloric acid, a saturated sodium hydrogen carbonate solution and saturated brine and dried over anhydrous sodium sulfate. The solvent was removed in vacuo and the residue was purified by recrystallization to give the subject compound (2.18 g, 52%).

1. customThe solvent was removed in vacuo
2. additionthe residue was diluted with chloroform
3. washThe organic layer was washed with water, 1N hydrochloric acid
4. dry with materiala saturated sodium hydrogen carbonate solution and saturated brine and dried over anhydrous sodium sulfate
5. customThe solvent was removed in vacuo
6. customthe residue was purified by recrystallization