反应详情

温度

50 °C

To (R)-methyl lactate (24.42 g, 0.23 mol) were added morphline (21.46 g, 0.25 mol) and sodium methoxide in methanol (14%, 9.04 g, 0.02 mol) and the mixture was stirred for 3 hours at 50° C. After removal of the solvent in vacuo, the residue was subjected to azeotropic distillation three times with toluene to give the subject compound (quant.).

1. customAfter removal of the solvent in vacuo
2. distillationthe residue was subjected to azeotropic distillation three times with toluene
3. customto give the subject compound (quant.)