Imidazole → HCID 68463439, compound

Participants

Reaction Steps

To imidazole (6.80 g, 100 mmol) in pyridine (30 ml) was added triethylamine (20.2 g, 200 mmol) and the mixture was stirred under ice cooling. Therein was dropped p-toluoyl chloride (30.9 g, 200 mmol) in a period of 10 minutes. After addition of pyridine (70 ml) the mixture was stirred for 3 hours at room temperature. Thereto was added 4N aqueous sodium hydroxide solution (100 ml) and the mixture was stirred 3 hours at 80° C. The reaction mixture was allowed to stand at room temperature. After addition of water (200 ml), the mixture was stirred to give crystals. The crystals were taken by filtration and washed with water-methanol (1:1) to give the subject compound (9.83 g, 51%).

Provenance & Evidence