Methanol → HCID 59430737, compound

Participants

Reaction Steps

To the compound of Example 1-1 (410 mg, 0.95 mmol) in THF (4 ml) were added methanol (4 ml) and 1N aqueous lithium hydroxide solution (4 ml), followed by stirring for 8 hours at room temperature. The reaction mixture was diluted with water and washed with diethyl ether. To the aqueous layer was added 5% aqueous potassium hydrogen sulfate solution and the solution was adjusted around pH3 and extracted with ethyl acetate. The organic layer was washed with water, saturated brine, dried over magnesium sulfate and filtered. The solvent was removed in vacuo to give the subject compound (262 mg, 66%).

Provenance & Evidence