Hydrochloric Acid → HCID 59430951, compound

Participants

Reaction Steps

The compound of Example 39-1 (114 mg, 0.20 mmol) was dissolved in methanol (0.75 ml) and THF (0.75 ml) and thereto was added 2N aqueous lithium hydroxide solution (0.2 ml), followed by stirring under reflux for 4 hours. After being cooled to room temperature, the solution was adjusted around pH2 with 1N diluted hydrochloric acid. The solution was extracted with ethyl acetate and the organic layer was washed with saturated brine, dried over magnesium sulfate and filtered. The solvent was removed in vacuo to give the subject compound (99 mg, 92%).

Provenance & Evidence