Lithium Hydroxide → HCID 59430962, compound

Participants

Reaction Steps

The compound of Example 40-1 (142 mg, 0.26 mmol) was dissolved in methanol (1 ml) and THF (1 ml) and thereto was added 2N lithium hydroxide solution (0.5 ml), followed by stirring under reflux for 15 hours. The reaction mixture was diluted with water and washed with diethyl ether. The aqueous layer was adjusted to around pH4 with 5% aqueous potassium hydrogen sulfate solution and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and filtered. The solvent was removed in vacuo to give the subject compound (39 mg, 31%).

Provenance & Evidence