HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanedione--ethanol (1/1) → (3R,3aS)-2-(4-cyano-3-methylphenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanedione--ethanol (1/1) | HCID 19604758 | — |
| Reactant | 2-(4-cyano-3-methylphenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid | HCID 24983912 | — |
| Product | (3R,3aS)-2-(4-cyano-3-methylphenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid | HCID 59429373 | — |
Reaction Steps
The title compound was prepared from the 2-(4-cyano-3-methylphenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid prepared in Example 21 using chiral resolution (e.g., Method G (Chiralcel OJ-H 30×250 mm; 50% ethanol/carbon dioxide). Second eluting peak: chiral HPLC tR=3.49 minutes (Chiralcel OJ-H 4.6×250 mm; 50% ethanol/carbon dioxide)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781428B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-d21d09235e5f45209dcefe43ffad17cd |
| Source note | uspto-grants-2010_08 |