4-Hydrazinyl-2-(trifluoromethyl)benzonitrile hydrochloride → 2-[4-Cyano-3-(trifluoromethyl)phenyl]-3-cyclopentyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole-7-carboxylic acid

Participants

Reaction Steps

The title compound was prepared from methyl 3-(cyclopentylmethylene)-4-oxochroman-7-carboxylate (Preparation 31; 286 mg, 1.0 mmol) and 4-hydrazinyl-2-(trifluoromethyl)benzonitrile hydrochloride (Preparation 3; 298 mg, 1.3 mmol) according to Method B and Method C. The title compound was largely present as a mixture of cis and trans diastereomers:

Provenance & Evidence