反应详情

A solution of 3-(3-pyridinyl)-2-propynol (500 mg, 3.75 mmol) in CH2Cl2 (5 mL) was treated with activated manganous dioxide (3.3 g, 34.5 mmol) at 25° C. After 12 h, the reaction mixture was filtered through celite, washed with CH2Cl2 (2×50 mL), concentrated in vacuo. Purification by flash chromatography afforded the title compound (100 mg, 20%) as yellow brown oil. MS 133 (M+H)+.

1. filtrationthe reaction mixture was filtered through celite
2. washwashed with CH2Cl2 (2×50 mL)
3. concentrationconcentrated in vacuo
4. customPurification by flash chromatography