反应详情

A solution (1 M) of methyl 4-nitro-5-[(E)-2-phenylethenyl]thiophene-2-carboxylate in triethyl phosphite was heated to reflux for 28 h. After cooling down a part of the solvent was evaporated under high vacuum (2 mbar, water bath 60° C.) then the residue was purified by flash chromatography on silica gel (1:4 acetone/toluene) to afford the title compound (32%) as a solid.

1. temperatureto reflux for 28 h
2. temperatureAfter cooling down a part of the solvent
3. customwas evaporated under high vacuum (2 mbar, water bath 60° C.)
4. customthe residue was purified by flash chromatography on silica gel (1:4 acetone/toluene)