反应详情

A solution (0.07 M) of methyl 6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylate in THF/MeOH (1:1) was treated with aqueous NaOH (2 N solution, 15 eq.). The mixture was heated to reflux for 90 min then concentrated and acidified to pH 1 with aqueous HCl (6 N) and extracted with AcOEt. The combined organic phase was washed with brine then dried and concentrated to give the title compound (93%) as a solid.

1. temperatureThe mixture was heated
2. temperatureto reflux for 90 min
3. concentrationthen concentrated
4. extractionextracted with AcOEt
5. washThe combined organic phase was washed with brine
6. customthen dried
7. concentrationconcentrated