HCID 68471639, compound → HCID 68469890, compound

HRID 505781Notes

Reaction equation

HRID 505781 reaction equation
C([O:5][C:6](=[O:32])[CH2:7][N:8]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:11]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:10]2[S:25][C:26]([C:28]([O:30][CH3:31])=[O:29])=[CH:27][C:9]1=2)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH:19]1([C:11]2[C:10]3[S:25][C:26]([C:28]([O:30][CH3:31])=[O:29])=[CH:27][C:9]=3[N:8]([CH2:7][C:6]([OH:32])=[O:5])[C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 1

HCID 68471639HCID 68471639, compound

Product 1

HCID 68469890HCID 68469890, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution (0.1 M) of methyl 4-(2-tert-butoxy-2-oxoethyl)-6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylate in DCM/TFA (1:1) was stirred at RT for 4 h. Evaporation of the solvent gave the title compound (100%) as a solid.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-3d23cd421d384d74b783353344e97d37
Source dataset
uspto-grants-2010_08
Patent number
US07781431B2

Reaction notes

Loading…