HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 505795Generated: November 3, 2026
Triethylsilane → methyl 5-(4-chlorophenyl)-6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylate
https://huagongshe.com/reaction/505795
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | methyl 5-(4-chlorophenyl)-6-cyclohex-1-en-1-yl-4H-thieno[3,2-b]pyrrole-2-carboxylate | HCID 68467153 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | methyl 5-(4-chlorophenyl)-6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylate | HCID 68472408 | 99% |
Reaction Steps
A solution (0.11 M) of methyl 5-(4-chlorophenyl)-6-cyclohex-1-en-1-yl-4H-thieno[3,2-b]pyrrole-2-carboxylate in TFA at 0° C. was treated with triethylsilane (1.5 eq.). The reaction mixture was stirred at 0° C. for 2 h then solvent was evaporated to give the title compound (99%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07781431B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-ae4bbb4715ab489abe23777c3eafb636 |
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| Source note | uspto-grants-2010_08 |
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