HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(cyclohex-1-enyl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid → 6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(cyclohex-1-enyl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid | HCID 58679083 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | 6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid | HCID 58679096 | 98% |
Reaction Steps
A solution (0.1 M) of 6-cyclohex-1-en-1-yl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid in MeOH/AcOEt (2:1) was treated with 20% Pd(OH)2/C (10% wt.). The resulting suspension was stirred for 18 h under 45 psi of hydrogen then purged with nitrogen and filtered. The filtrate was concentrated to afford the title compound (98%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781431B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-f5c7bcc51b6e4a439a896d179c06b6b8 |
| Source note | uspto-grants-2010_08 |