HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1-Boc-piperidine → 1,1-Dimethylethyl 4-[({[2-(ethyloxy)-2-oxoethyl]oxy}carbonyl)amino]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Reactant | Ethyl [(phenoxycarbonyl)oxy]acetate | HCID 12094709 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1,1-Dimethylethyl 4-[({[2-(ethyloxy)-2-oxoethyl]oxy}carbonyl)amino]piperidine-1-carboxylate | HCID 68465074 | — |
Reaction Steps
A suspension of 5.09 g (25.42 mmol) of 1,1-dimethylethyl 4-aminopiperidine-1-carboxylate and 13.45 g (59.99 mmol) of ethyl [(phenyloxycarbonyl)oxy]acetate (J. Med. Chem., 1999, 42, 277-90) in 300 ml of toluene is heated at reflux for 30 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781590B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-2370f5c8e8374cbea93b091642512d3f |
| Source note | uspto-grants-2010_08 |