Pyridine → HCID 68464581, compound

HRID 505958Notes

Reaction equation

HRID 505958 reaction equation
[Cl:1][C:2]1[C:7]([S:8]([N:11]=[CH:12][N:13]([CH3:15])[CH3:14])(=[O:10])=[O:9])=[CH:6][C:5]([CH2:16][NH:17][CH:18]2[CH2:23][CH:22]([CH3:24])[CH2:21][C:20]([CH3:26])([CH3:25])[CH2:19]2)=[CH:4][CH:3]=1.[CH3:27][S:28](Cl)(=[O:30])=[O:29].N1C=CC=CC=1>C(Cl)Cl>[Cl:1][C:2]1[C:7]([S:8]([N:11]=[CH:12][N:13]([CH3:15])[CH3:14])(=[O:10])=[O:9])=[CH:6][C:5]([CH2:16][N:17]([CH:18]2[CH2:23][CH:22]([CH3:24])[CH2:21][C:20]([CH3:25])([CH3:26])[CH2:19]2)[S:28]([CH3:27])(=[O:30])=[O:29])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 68466516HCID 68466516, compound

Product 1

HCID 68464581HCID 68464581, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound is obtained as an oil by reacting 6-chloro-N-dimethylaminomethylene-3-[(3,3,5-trimethylcyclohexylamino)methyl]benzenesulfonamide with methanesulfonyl chloride in methylene chloride in the presence of pyridine as auxiliary base and by purification by column chromatography (silica gel, methylene chloride:methanol=95:5).

Workup

  1. customThis compound is obtained as an oil
  2. customby purification by column chromatography (silica gel, methylene chloride:methanol=95:5)

Sources & evidence

ORD record
ord-0c644ec2be5e420b9eca383299df5471
Source dataset
uspto-grants-2010_08
Patent number
US07781613B2

Reaction notes

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