HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylacetylene → 5-(4-Chloro-phenyl)-6-(2-cyclopropyl-ethyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylacetylene | HCID 138823 | — |
| Reactant | 6-chloro-5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide | HCID 86619184 | — |
| Product | 5-(4-Chloro-phenyl)-6-(2-cyclopropyl-ethyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide | HCID 24797443 | — |
Reaction Steps
The title compound was synthesized in analogy to Examples 1d tole, using 6-chloro-5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide and ethynylcyclopropane as starting materials; yield 189 mg, 46% over two steps; m/z (ISP+): 399.2, 401.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781593B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-4d27c0fb05884b8f81db188aaa6a2f6c |
| Source note | uspto-grants-2010_08 |