Trifluoroacetic anhydride → HCID 131728306, compound

Participants

Reaction Steps

A mixture comprising trifluoroacetic anhydride (25.6 g) and 3-bromopropionic acid (17.9 g) was stirred at room temperature under a nitrogen stream for 1 hour. CF3CF2CF2OCF(CF3)CF2OCF(CF3)CH2OH (55.9 g) was added dropwise thereto while cooling with water so that the internal temperature would be maintained to be 30° C. or lower over a period of 30 minutes. 3 hours later, the reaction liquid was directly concentrated and purified by silica gel column chromatography (eluent: mixed solvent comprising hexane (10): ethyl acetate (1)) to obtain the title compound (54.6 g). The yield: 80%.

Provenance & Evidence