HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → HCID 11589308, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 59425169 | HCID 59425169 | — |
| Reactant | HCID 59426360 | HCID 59426360 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | HCID 11589308 | HCID 11589308 | — |
Reaction Steps
Following the procedure in example 1B step B, 2-[4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl]-1-ethyl-6-hydroxy-1H-indole-3-carbonitrile, K2CO3, 2-iodopropane and methyl ethyl ketone are heated at reflux to give, after flash chromatography (EtOAc/CH2Cl2, 0-2%), 61% of 2-[4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl]-1-ethyl-6-isopropoxy-1H-indole-3-carbonitrile as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781478B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-883a080e1f2140dba46aa049a49befd1 |
| Source note | uspto-grants-2010_08 |