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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 506167Generated: November 1, 2026

7-Methyl-1H-indol-5-amine → 5-(3,4-dimethoxyphenyl)-4-(7-methyl-1H-indol-5-ylamino)nicotinonitrile

https://huagongshe.com/reaction/506167

Reaction equation

Participants

RoleNameHCIDCharge
Reactant7-Methyl-1H-indol-5-amineHCID 15434501—
Reactant5-(3-bromophenyl)-4-(1H-indol-5-ylamino)nicotinonitrileHCID 24866681—
Reactant4-Chloro-5-(3,4-dimethoxyphenyl)nicotinonitrileHCID 25129785—
Product5-(3,4-dimethoxyphenyl)-4-(7-methyl-1H-indol-5-ylamino)nicotinonitrileHCID 44573900—

Reaction Steps

Following procedures analogous to those described for preparing compound 113 (Example 2, Method B), the title compound was prepared from 4-chloro-5-(3,4-dimethoxyphenyl)nicotinonitrile and 5-amino-7-methylindole. MS: 385.3 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07781591B2
Source datasetuspto-grants-2010_08
ORD IDord-34a78f18d3634db19cda05bfc27ded4f
Source noteuspto-grants-2010_08