Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 178510337 | HCID 178510337 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178510339 | HCID 178510339 | 61.3% |
Reaction Steps
A mixture of 4-hydroxynicotinonitrile (45.7 g, 381 mmol), iodine (96.6 g, 381 mmol) and NaOH (19.8 g, 825 mmol) in water (600 mL) was heated at 85° C. overnight, cooled to r.t. and diluted with water. The precipitate was collected by filtration and washed with water to give 57.5 g (61%) of 4-hydroxy-5-iodonicotinonitrile as a tan solid. Mp>245° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07781591B2 |
|---|
| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-a88d4654205b49ecac2b716b56ed3020 |
|---|
| Source note | uspto-grants-2010_08 |
|---|
