HRID506175
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 80 °C
PROCEDURE
实验过程
To a mixture of 5-iodo-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile (200 mg, 0.53 mmol), 2-benzofuranboronic acid (173 mg, 1.07 mmol) and Pd(PPh3)4 (31 mg, 0.027 mmol) in DME (4.0 mL) was added 2.0 M aqueous Na2CO3 (0.8 mL). The resulting mixture was heated at 80° C. for 2 h, cooled to r.t. and filtered. The filtrate was concentrated and purified by HPLC to give 35 mg of 5-(1-benzofuran-2-yl)-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile 222 as a yellow solid. MS: 365.2 (M+H); HPLC retention time: 11.4 min.(a).
WORKUP
后处理
- temperaturecooled to r.t.
- filtrationfiltered
- concentrationThe filtrate was concentrated
- custompurified by HPLC