5-Nitroindole → HCID 68466474, compound

HRID 506182Notes

Reaction equation

HRID 506182 reaction equation
[CH3:1][CH2:2][Mg+].[Br-].[N+:5]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[CH:11]2)([O-])=O>[Pd]>[NH2:5][C:8]1[C:9]([CH2:2][CH3:1])=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[CH:11]2

Participants

4

Reactant 2

HCID 225235-NitroindoleHCID 178461630HCID 178461630, compound

Product 1

HCID 68466474HCID 68466474, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Addition of EtMgBr to 5-nitroindole followed by hydrogenation over Pd/C provided 5-amino-4-ethylindole.

Sources & evidence

ORD record
ord-e21b0870b68841a790eec054f0253330
Source dataset
uspto-grants-2010_08
Patent number
US07781591B2

Reaction notes

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