1-(2-Hydroxyethyl)-4-methylpiperazine → 1-[2-(4-Bromo-3-chlorophenoxy)ethyl]-4-methyl-piperazine

HRID 506184Notes

Reaction equation

HRID 506184 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[Cl:9].[CH3:10][N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18]O)[CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:18][CH2:17][N:14]2[CH2:15][CH2:16][N:11]([CH3:10])[CH2:12][CH2:13]2)=[CH:4][C:3]=1[Cl:9]

Participants

3

Reactant 2

HCID 2311841-(2-Hydroxyethyl)-4-methylpiperazineHCID 70181824-Bromo-3-chlorophenol

Product 1

HCID 684633641-[2-(4-Bromo-3-chlorophenoxy)ethyl]-4-methyl-piperazine

Procedure

4-Bromo-3-chlorophenol was reacted with 1-methyl-4-(2-hydroxyethyl)piperazine under the Mitsunobu conditions to provide 1-[2-(4-bromo-3-chlorophenoxy)ethyl]-4-methyl-piperazine.

Sources & evidence

ORD record
ord-41a9ea67e7584d049f4c57cb310e93f9
Source dataset
uspto-grants-2010_08
Patent number
US07781591B2

Reaction notes

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