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Triisopropyl borate → Diisopropyl 2-chloro-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenylboronate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triisopropyl borate | HCID 21531 | — |
| 反応物 | 1-[2-(4-Bromo-3-chlorophenoxy)ethyl]-4-methyl-piperazine | HCID 68463364 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | Diisopropyl 2-chloro-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenylboronate | HCID 68466082 | — |
反応手順
1-[2-(4-Bromo-3-chlorophenoxy)ethyl]-4-methyl-piperazine was reacted with n-BuLi at 0° C. in the presence of triisopropyl borate to give diisopropyl 2-chloro-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenylboronate upon warming to room temperature.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07781591B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-244fd642624a43baa212d90fc9b93e33 |
| 出典メモ | uspto-grants-2010_08 |