HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4,5-Trimethylpyridine → Benzofuran-5-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4,5-Trimethylpyridine | HCID 14280 | — |
| Reactant | 5-Methoxybenzofuran | HCID 25943 | — |
| Reactant | Lithium iodide | HCID 66321 | — |
| Product | Benzofuran-5-ol | HCID 11651159 | — |
Reaction Steps
5-Methoxybenzofuran was treated with 2,4,5-collidine and LiI at 170° C. to provide benzofuran-5-ol, which was reacted with 2-chloroethyl-p-toluenesulfonate and Cs2CO3 to give 5-(2-chloroethoxy)-1-benzofuran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781591B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-2060e06ae984460ca08857a73c4aef75 |
| Source note | uspto-grants-2010_08 |