HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 5-Chloro-2-phenylbenzoxazole-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 5-chloro-2-phenyl-benzoxazole-7-carboxylate | HCID 68454443 | — |
| Product | 5-Chloro-2-phenylbenzoxazole-7-carboxylic acid | HCID 68456500 | 82% |
Reaction Steps
5-Chloro-2-phenylbenzoxazole-7-carboxylic acid was prepared from methyl 5-chloro-2-phenyl-benzoxazole-7-carboxylate via lithium hydroxide mediated hydrolysis as described in Step B of Example 14. This material was obtained as a white solid in 82% yield. 1H NMR (300 MHz, DMSO-d6) δ 13.84 (br s, 1H), 8.22-8.19 (m, 3H), 7.85 (d, J=2.1 Hz, 1H), 7.70-7.63 (m, 3H), 4.07 (s, 3H); MS (ESI) m/z 274 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781430B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-945d2baad0494423afb1666aca8cfc33 |
| Source note | uspto-grants-2010_08 |