HCID 86610568, compound → HCID 86610567, compound

Participants

Reaction Steps

(2R*,4S*)-4-({5-[2-(Benzyloxycarbonylamino)acetylamino]pyrimidin-2-yl}-[3,5-bis(trifluoromethyl)benzyl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-[1,5]naphthyridine-1-carboxylic acid ethyl ester (631 mg) is dissolved in methanol (10 ml), 10% palladium/carbon (100 mg) is added thereto and then the mixture is stirred at room temperature under hydrogen for 30 minutes. The reaction solution is filtered, and concentrated under reduced pressure. The resulting residue is purified by column chromatography (silica gel; chloroform:methanol=1:0→9:1) to give (2R*,4S*)-4-{[5-(2-aminoacetylamino)pyrimidin-2-yl]-[3,5-bis(trifluoromethyl)benzyl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-[1,5]naphthyridine-1-carboxylic acid ethyl ester (463 mg). MS (m/z): 626 [M+H]+

Provenance & Evidence