Toluene → HCID 59432159, compound

Participants

Reaction Steps

At RT, 51.5 g (226 mmol) of periodic acid and 9.9 g (99 mmol) of CrO3 were dissolved in acetonitrile/water. Furthermore, 25 g (90.3 mmol) of 4-fluoro-N-(1-hydroxymethylallyl)-2-trifluoromethylbenzamide were dissolved in acetonitrile/water and the NalO4/CrO3 solution which had been prepared earlier was added dropwise at 0-5° C. over a period of 3 h. The mixture was then stirred at RT for 15 h. 400 ml of 6% strength Na2HPO4 solution were then added dropwise, toluene and ethyl acetate were added and the phases were separated. The aqueous phase was re-extracted with ethyl acetate. The combined organic phases were washed, dried and concentrated. This gave 24.1 g (92% of theory) of the title compound.

Provenance & Evidence