Methylamine → N-(2-Hydroxy-1-methylcarbamoylbut-3-enyl)-4-fluoro-2-trifluoromethylbenzamide

Participants

Reaction Steps

4.5 g (12.9 mmol) of ethyl 3-hydroxy-2-(4-fluoro-2-trifluoromethylbenzoylamino)pent-4-enoate were dissolved in methanol. With ice cooling methylamine gas was introduced for 2 h. The reaction solution was then concentrated and washed. This gave 3.1 g (80% of theory) of the title compound as a colorless solid (diastereomer ratio 2:1).

Provenance & Evidence