HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Difluoromethoxy)-3-methoxybenzaldehyde → 4-Trifluoroethoxy-3-hydroxybenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Difluoromethoxy)-3-methoxybenzaldehyde | HCID 3161249 | — |
| Reactant | 3-Methoxy-4-(2,2,2-trifluoroethoxy)benzaldehyde | HCID 12647499 | — |
| Product | 4-Trifluoroethoxy-3-hydroxybenzaldehyde | HCID 86625225 | 81% |
Reaction Steps
Repeating Example 3, except that 4-difluoromethoxy-3-methoxybenzaldehyde was replaced with 70 grams (0.3 mol) of 4-trifluoroethoxy-3-methoxybenzaldehyde to give 4-trifluoroethoxy-3-hydroxybenzaldehyde (m.p. 133˜135° C.) in a yield of 81%. 1H-NMR (ppm) δ: 9.81 (1H, s; —CHO); 7.26 (1H, m; 6-ArH); 7.17 (1H, m; 2-ArH); 6.79 (1H, m; 5-ArH); 4.88 (1H, s; —OH); 4.45 (2H, q; J3H-F=7.2 Hz; —CH2CF3). 13C-NMR (ppm)) δ: 191.0 (CHO), 157.2 (4-ArC), 146.2 (3-ArC), 130.6 (1-ArC), 126 (q, CF3), 123.5 (6-ArC), 116.7 (2-ArC), 116.2 (5-ArC), 87 (m, CH2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786098B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-2a67233422e4413da91b39fe13040fd8 |
| Source note | uspto-grants-2010_08 |