HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 6-Methoxy-1,2,3,4-tetrahydroquinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Hydroxy-3,4-dihydro-2(1H)-quinolinone | HCID 2774040 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Methoxy-1,2,3,4-tetrahydroquinolin-2-one | HCID 10888467 | 62.9% |
Reaction Steps
6-Hydroxy-3,4-dihydroquinolin-2(1H)-one (18.38 mmol, 3.00 g) was treated in the presence of K2CO3 (22.98 mmol, 3.18 g) with methyl iodide (22.98 mmol, 3.26 g) in N,N-dimethylformamide (30 ml) at room temperature for 24 hours, resulting in 2.05 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786105B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-7e61c7c6bc4f48da8347628a80405a2b |
| Source note | uspto-grants-2010_08 |