5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid → HCID 68432712, compound

HRID 506509Notes

Reaction equation

HRID 506509 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=1)[C:6]([C:19](O)=[O:20])=[CH:5]2.[N:22]1([C:27]2[N:32]=[CH:31][C:30]([NH2:33])=[CH:29][N:28]=2)[CH2:26][CH2:25][CH2:24][CH2:23]1>>[N:22]1([C:27]2[N:28]=[CH:29][C:30]([NH:33][C:19]([C:6]3[N:7]([CH2:11][C:12]4[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=4)[C:8]4[C:4]([CH:5]=3)=[CH:3][C:2]([F:1])=[CH:10][CH:9]=4)=[O:20])=[CH:31][N:32]=2)[CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 574315135-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acidHCID 57431520HCID 57431520, compound

Product 1

HCID 68432712HCID 68432712, compound

Procedure

The process is carried out according to the method described in example 2, using 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid (example 1.1) and 2-(pyrrolidin-1-yl)-5-aminopyrimidine (US 20060281772).

Sources & evidence

ORD record
ord-679a0962add844788b9d13c672ca0193
Source dataset
uspto-grants-2010_08
Patent number
US07786104B2

Reaction notes

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