HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(5-Nitropyridin-2-yl)azetidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Reactant | 3-Hydroxyazetidine hydrochloride | HCID 2759290 | — |
| Product | 1-(5-Nitropyridin-2-yl)azetidin-3-ol | HCID 52937264 | 95.7% |
Reaction Steps
The process is carried out according to the method described in step 5.1, using 7 g (42.83 mmol) of 2-chloro-5-nitropyridine and 5.75 g (51.4 mmol) of 3-azetidinol hydrochloride. In this case, 13 g (128.45 mmol) of triethylamine are also added. 8 g of the expected product are thus isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786104B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-53756dc0e3634078b643de2e7cd96c7f |
| Source note | uspto-grants-2010_08 |