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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 506523Generated: October 26, 2026

1-(5-Aminopyridin-2-yl)azetidin-3-ol → N-[6-(3-Hydroxyazetidin-1-yl)pyridin-3-yl]-1-(3-fluorobenzyl)-5-trifluoromethyl-1H-indole-2-carboxamide

https://huagongshe.com/reaction/506523

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(5-Aminopyridin-2-yl)azetidin-3-olHCID 57431525—
Reactant5-trifluoromethyl-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acidHCID 57431532—
ProductN-[6-(3-Hydroxyazetidin-1-yl)pyridin-3-yl]-1-(3-fluorobenzyl)-5-trifluoromethyl-1H-indole-2-carboxamideHCID 57431500—

Reaction Steps

The process is carried out according to the method described in example 2, using 5-trifluoromethyl-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid (WO 2006/072736) and 2-(3-hydroxyazetidin-1-yl)-5-aminopyridine, prepared in step 10.2 of example 10 (Compound Ve).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07786104B2
Source datasetuspto-grants-2010_08
ORD IDord-81ca14cdeb554732bca3679f237045bb
Source noteuspto-grants-2010_08