反应详情

A solution of 2.1 g (7.04 mmol) of ethyl 5-fluoro-1-[(pyridin-4-yl)methyl]-1H-indole-2-carboxylate (WO 2007/010144) and of 1.18 g (21.12 mmol) of potassium hydroxide in 80 ml of ethanol and 2 ml of water is refluxed for 2 hours. The reaction mixture is subsequently concentrated under reduced pressure. 100 ml of water are added and the pH of the solution is brought to pH 8 by the addition of a concentrated hydrochloric acid solution. A precipitate is recovered by filtration and is washed with water and then dried under reduced pressure. 1.5 g of the expected product are thus obtained.

1. concentrationThe reaction mixture is subsequently concentrated under reduced pressure
2. addition100 ml of water are added
3. additionthe pH of the solution is brought to pH 8 by the addition of a concentrated hydrochloric acid solution
4. filtrationA precipitate is recovered by filtration
5. washis washed with water
6. customdried under reduced pressure