HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-hydroxy-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | o-(1-Piperazinyl)phenol | HCID 70530 | — |
| Reactant | Methanesulfonic acid 1-[1-(4-chloro-phenyl)-cyclobutanecarbonyl]-piperidin-3-ylmethyl ester | HCID 12992442 | — |
| Product | [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-hydroxy-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone | HCID 12992449 | 32% |
Reaction Steps
Compound 12 was prepared using the method described in Example 3, starting with compound 2 (1.0 g, 2.60 mmol), 1-(2-hydroxyphenyl)piperazine (0.51 g, 2.86 mmol), and cesium carbonate (1.27 g, 3.90 mmol) to give 12 (0.39 g, 32%); C27H34ClN3O2, LRMS (m/z)=469 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713479B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-accaef0e7dab46b7aed1f6587ecaf26d |
| Source note | uspto-grants-2004_03 |