Acetone → 1-(4-Isopropylphenyl)-2-methylpropan-2-ol

HRID 506546Notes

Reaction equation

HRID 506546 reaction equation
[CH:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH3:12][C:13]([CH3:15])=[O:14]>>[CH:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][C:13]([CH3:15])([OH:14])[CH3:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 180AcetoneHCID 749164-Isopropylbenzyl chloride

Product 1

HCID 220634861-(4-Isopropylphenyl)-2-methylpropan-2-ol

Procedure

The reaction of a Grignard compound, prepared from 20 g (119 mmol) 4-isopropylbenzyl chloride, with 11.4 mL (155 mmol) acetone yields the target compound as a colorless oil. Yield: 13.0 g (57%); mass spectrometry: [M+H]+=193.

Workup

  1. customThe reaction of a Grignard compound

Sources & evidence

ORD record
ord-fa3df29457a94821ba4e17c96c554499
Source dataset
uspto-grants-2010_08
Patent number
US07786111B2

Reaction notes

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