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Benzaldehyde → 4-(2-(Diethylamino)-Ethoxy)-Benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | 1-Chloro-2-(diethylamine)ethane hydrochloride | HCID 13363 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(2-(Diethylamino)-Ethoxy)-Benzaldehyde | HCID 411674 | — |
反応手順
4.82 g potassium hydroxide were dissolved in 70 ml ethanol and treated with 8.46 g (2-Chloro-ethyl)-diethyl-amine hydrochloride. The mixture was stirred until everything was dissolved, then 5.0 g benzaldehyde were added and refluxed for 16 hrs. The mixture was diluted with water and extracted with ethyl acetate, and the organic phases washed several times with caustic soda. After drying and evaporation of the solvent the crude product was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07786113B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-ccd87d0fe8414c9aaec4f9b0b134d9ca |
| 出典メモ | uspto-grants-2010_08 |